Jessie is a Mars, she is a masculine female. She is female on the inside and identifies herself with other women. However, she enjoys expressing herself with masculine clothes and has a passionate personality.
James is a Mercury, as a feminine male. He is male on the inside and identifies himself with other men. However, he enjoys expressing himself as highly intelligent and female.
Meowth is a Venus, very expressive and open about his wants.
Unfortunately, the couple does buy into the idea that gays and transgender are evil by nature, which is bullshit. Being the opposite gender improves your perception of reality.